Medrol shortage: what should I do? , Can you crush
Medrol shortage: what should I do? , Can you crush
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Scottguild
ゲストIceberg flotillas
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Located on the west coast, Ilulissat is a pretty halibut- and prawn-fishing port on a dark rock bay where visitors can sit in pubs sipping craft beers chill-filtered by 100,000-year-old glacial ice.It’s a place to be awed by the UNESCO World Heritage Icefjord where Manhattan skyscraper-sized icebergs disgorge from Greenland’s icecap to float like ghostly ships in the surrounding Disko Bay.
Small boats take visitors out to sail closely among the bay’s magnificent iceberg flotilla. But not too close.
“I was on my boat once and saw one of these icebergs split in two. The pieces fell backwards into the sea and created a giant wave,” said David Karlsen, skipper of the pleasure-boat, Katak. “…I didn’t hang around.”
Disko Bay’s other giants are whales. From June to September breaching humpback whales join the likes of fin and minke whales feasting on plankton. Whale-watching is excellent all around Greenland’s craggy coastline.
Whales are eaten here. Visitors shouldn’t be surprised to encounter the traditional Greenlandic delicacy of mattak — whale-skin and blubber that when tasted is akin to chewing on rubber. Inuit communities have quotas to not only hunt the likes of narwhals but also polar bears, musk-ox and caribou — which can also appear on menus.
Chesterjoype
ゲストCuriosity has maintained pristine pieces of the Cumberland sample in a “doggy bag” so that the team could have the rover revisit it later, even miles away from the site where it was collected. The team developed and tested innovative methods in its lab on Earth before sending messages to the rover to try experiments on the sample.
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In a quest to see whether amino acids, the building blocks of proteins, existed in the sample, the team instructed the rover to heat up the sample twice within SAM’s oven. When it measured the mass of the molecules released during heating, there weren’t any amino acids, but they found something entirely unexpected.An intriguing detection
The team was surprised to detect small amounts of decane, undecane and dodecane, so it had to conduct a reverse experiment on Earth to determine whether these organic compounds were the remnants of the fatty acids undecanoic acid, dodecanoic acid and tridecanoic acid, respectively.The scientists mixed undecanoic acid into a clay similar to what exists on Mars and heated it up in a way that mimicked conditions within SAM’s oven. The undecanoic acid released decane, just like what Curiosity detected.
Each fatty acid remnant detected by Curiosity was made with a long chain of 11 to 13 carbon atoms. Previous molecules detected on Mars were smaller, meaning their atomic weight was less than the molecules found in the new study, and simpler.
“It’s notable that non-biological processes typically make shorter fatty acids, with less than 12 carbons,” said study coauthor Dr. Amy Williams, associate professor of geology at the University of Florida and assistant director of the Astraeus Space Institute, in an email. “Larger and more complex molecules are likely what are required for an origin of life, if it ever occurred on Mars.”Rodgerthods
ゲストRemote and rugged
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A more organic way to see this coast is by the multi-day coastal ferry, the long-running Sarfaq Ittuk, of the Arctic Umiaq Line. It’s less corporate than the modern cruise ships and travelers get to meet Inuit commuters. Greenland is pricey. Lettuce in a local community store might cost $10, but this coastal voyage won’t break the bank.The hot ticket currently for exploring Greenland’s wilder side is to head to the east coast facing Europe. It’s raw and sees far fewer tourists, with a harshly dramatic coastline of fjords where icebergs drift south. There are no roads and the scattered population of just over 3,500 people inhabit a coastline roughly the distance from New York to Denver.
A growing number of small expedition vessels probe this remote coast for its frosted scenery and wildlife. Increasingly popular is the world’s largest fjord system of Scoresby Sound with its sharp-fanged mountains and hanging valleys choked by glaciers. Sailing north is the prosaically named North East Greenland National Park, fabulous for spotting wildlife on the tundra.
Travelers come to see polar bears which, during the northern hemisphere’s summer, move closer to land as the sea-ice melts. There are also musk oxen, great flocks of migrating geese, Arctic foxes and walrus.
Some of these animals are fair game for the local communities. Perhaps Greenland’s most interesting cultural visit is to a village that will take longer to learn how to pronounce than actually walk around — Ittoqqortoormiit. Five hundred miles north of its neighboring settlement, the 345 locals are frozen in for nine months of the year. Ships sail in to meet them during the brief summer melt between June and August.Locked in by ice, they’ve retained traditional habits.
“My parents hunt nearly all their food,” said Mette Barselajsen, who owns Ittoqqortoormiit’s only guesthouse. “They prefer the old ways, burying it in the ground to ferment and preserve it. Just one muskox can bring 440 pounds of meat.”
RogerZek
ゲストSiham Haleem, a private tour guide for 15 years, says that Doha now has many world-class, modern museums — the National Museum of Qatar being a firm personal favorite. And yet he says that visiting Sheikh Faisal’s museum should still be on everybody’s to-do list.
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“For those eager to learn about Qatar’s — and the region’s — heritage and beyond, the museum is an ideal destination,” he says. “Personally, I’m captivated by the car collection, the fossils, and especially the Syrian house, painstakingly transported and reassembled piece by piece.”Stephanie Y. Martinez, a Mexican-American student mobility manager at Texas A&M University in Qatar likes the museum so much she includes it on all of her itineraries for students visiting from the main campus in Texas.
“The guided tours are very detailed, and the collections found at the museum have great variety and so many stories to unfold,” she says. “Truly, the museum has something to pique everyone’s interest. My favorites are the cars and the furniture exhibits showcasing wood and mother-of-pearl details. Definitely one of my favorite museums in Qatar, every time I visit I learn something new.”
Raynor Abreu, from India, also had praise for the unusual and immense collection.
“Each item has its own story, making the visit even more interesting,” he says. “It’s also impressive to know that Sheikh Faisal started collecting these unique pieces when he was very young. Knowing this makes the museum even more special, as it reflects his lifelong passion for history and culture.”
It takes time and dedication to truly examine the many collections within the museum — especially since most of them are simply on display without explanation.
Eclectic it may be, but it’s hard to fault the determination of Sheikh Faisal, who has brought together items that tell the story of Qatar and the Middle East.
Sarah Bayley, from the UK, says she visited the museum recently with her family, including 16 and 19-year-old teenagers, and was won over by its sheer eccentricity.
“Amazing. Loved it. It is a crazy place.”
Davidtaugh
ゲストWhile the Cumberland sample may contain longer chains of fatty acids, SAM is not designed to detect them. But SAM’s ability to spot these larger molecules suggests it could detect similar chemical signatures of past life on Mars if they’re present, Williams said.
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“Curiosity is not a life detection mission,” Freissinet said. “Curiosity is a habitability detection mission to know if all the conditions were right … for life to evolve. Having these results, it’s really at the edge of the capabilities of Curiosity, and it’s even maybe better than what we had expected from this mission.”Before sending missions to Mars, scientists didn’t think organic molecules would be found on the red planet because of the intensity of radiation Mars has long endured, Glavin said.
Curiosity won’t return to Yellowknife Bay during its mission, but there are still pristine pieces of the Cumberland sample aboard. Next, the team wants to design a new experiment to see what it can detect. If the team can identify similar long-chain molecules, it would mark another step forward that might help researchers determine their origins, Freissinet said.“That’s the most precious sample we have on board … waiting for us to run the perfect experiment on it,” she said. “It holds secrets, and we need to decipher the secrets.”
Briony Horgan, coinvestigator on the Perseverance rover mission and professor of planetary science at Purdue University in West Lafayette, Indiana, called the detection “a big win for the whole team.” Horgan was not involved the study.
“This detection really confirms our hopes that sediments laid down in ancient watery environments on Mars could preserve a treasure trove of organic molecules that can tell us about everything from prebiotic processes and pathways for the origin of life, to potential biosignatures from ancient organisms,” Horgan said.Dr. Ben K.D. Pearce, assistant professor in Purdue’s department of Earth, atmospheric, and planetary sciences and leader of the Laboratory for Origins and Astrobiology Research, called the findings “arguably the most exciting organic detection to date on Mars.” Pearce did not participate in the research.
Jamesses
ゲストWellness perfectionism doesn’t exist. Focus on these sustainable habits
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ou’re scrolling through your phone when you stumble upon the next viral trend: an influencer claiming that following their incredibly strict diet will help you achieve their jaw-dropping physique. Or you see a fresh-faced runner swearing you can run a marathon without any training — just like they did.Whether or not you’re actively searching for wellness advice, it’s nearly impossible to avoid hearing about the latest health craze making bold guarantees of transformation.
As you wonder if these claims hold any truth, you might also question why people often feel motivated to dive into intense challenges — when seemingly simple habits, such as getting enough sleep or eating more vegetables, often feel much harder to tackle.
Many of us are drawn to these extreme challenges because we’re craving radical change, hoping it will help prove something to ourselves or to others, experts say.
“We always see these kinds of challenges as opportunities for growth, particularly if we’re in a phase of our life where we’ve let ourselves go,” said Dr. Thomas Curran, associate professor of psychology at the London School of Economics and Political Science and an expert on perfectionism. “Maybe we feel that we need to be healthier, or we just had a breakup or (major) life event.”
With social media amplifying these movements, it’s easy to see why people are increasingly drawn to the idea of achieving the “perfect” version of themselves. But before jumping into a new wellness challenge, it’s important to take a moment, reflect on your goals, and consider where you’re starting from.JosephCip
ゲストGreenland’s leader says US officials’ visit is ‘highly aggressive.’ Trump says it’s ‘friendliness, not provocation’
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Greenland’s prime minister said a planned visit to the island by US officials, including second lady Usha Vance, is “highly aggressive,” plunging relations to a new low after President Donald Trump vowed to annex the autonomous Danish territory.But despite the backlash, Trump has insisted the visit is about “friendliness, not provocation” – and claims the US team was “invited.”
Vance, the wife of US Vice President JD Vance, will travel to Greenland this week to watch the island’s national dogsled race and “celebrate Greenlandic culture and unity,” according to a statement from the White House. National security adviser Mike Waltz is also expected to visit the territory this week, according to a source familiar with the trip.
Greenland Prime Minister Mute B. Egede called the US delegation’s trip to the island “highly aggressive” in an interview with Greenlandic newspaper Sermitsiaq on Sunday, and raised particular objection to Waltz’s visit.
“What is the national security adviser doing in Greenland? The only purpose is to demonstrate power over us,” Egede said. “His mere presence in Greenland will no doubt fuel American belief in Trump’s mission — and the pressure will increase.”
Trump claimed on Monday that people in Greenland have responded warmly to the US’s recent interest in the territory. “They’re calling us. We’re not calling them. And we were invited over there,” he said.
“We’re dealing with a lot of people from Greenland that would like to see something happen with respect to them being properly protected and properly taken care of,” Trump told reporters following a meeting with his Cabinet.
“I think Greenland is going to be something that maybe is in our future,” Trump added.
The president said he believes Secretary of State Marco Rubio would be traveling to Greenland too.
Trump’s idea to annex Greenland has thrown an international spotlight on the territory, which holds vast stores of rare earth minerals critical for high-tech industries, and has raised questions about the island’s future security as the US, Russia and China vie for influence in the Arctic. Trump has repeatedly expressed interest in the US taking the island by force or economic coercion, even as Denmark and Greenland have firmly rejected the idea.
JosephMor
ゲストJessePromb
ゲストJosh Giddey hits halfcourt buzzer-beater over LeBron James to cap wild finale as the Bulls stun the Lakers
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Josh Giddey hit a game-winning, halfcourt buzzer-beater over LeBron James as the Chicago Bulls stunned the Los Angeles Lakers in one of the wildest endings to an NBA game you are ever likely to see.Trailing 115-110 with 12.6 seconds remaining, Giddey’s inbound pass found Nikola Vucevic, who pushed the ball to a wide-open Patrick Williams for a corner three-pointer.
James then fluffed the Lakers inbound pass from the baseline, allowing Giddey to steal the ball and find Coby White for a second Bulls triple in quick succession to put Chicago up 116-115 with 6.1 seconds remaining.
Austin Reaves then made a driving layup to put the Lakers ahead 117-116 with 3.3 seconds left, but the game wasn’t done yet.With no timeouts remaining, Giddey inbounded the ball to Williams from the baseline, got the pass back, took one dribble and launched a shot from beyond halfcourt.
Supporters in the stands seemed frozen in anticipation as the ball sailed through the air, and the United Center then erupted as it fell through the net. After the dramatic win, Giddey found himself being swarmed by his teammates.
“Special moment to do it with these guys, this team,” Giddey said, per ESPN. “We’ve shown over the last month to six weeks that we can beat anybody. The way we play the game, I think it wears people down.
“We get up and down. We run. We put heat on them to get back. A lot of veteran teams don’t particularly want to get back and play in transition.”
Giddey later told the Bulls broadcast that he’d “never made a game-winner before.”
The ending capped an incredible couple of games for the Lakers, who had themselves won their last game against the Indiana Pacers on Wednesday with a buzzer-beating tip-in from James.
Robertphill
ゲストFamily affair
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Americans Brittany and Blake Bowen had never even been to Ecuador when in 2021 they decided to move to the South American country with their four children.Tired of “long commutes and never enough money” in the US, the Bowens say they love their new Ecuadorian life. “We hope that maybe we’ll have grandkids here one day.”
Erik and Erin Eagleman moved to Switzerland from Wisconsin with their three children in 2023.
“It feels safe here,” they tell CNN of their new outdoorsy lifestyle in Basel, close to the borders with France and Germany. Their youngest daughter even walks to elementary school by herself.
For adventures with your own family, be it weekend breaks or something longer-term, our partners at CNN Underscored, a product review and recommendations guide owned by CNN, have this roundup of the best kids’ luggage sets and bags.
Starry, starry nights
For close to 100 years, Michelin stars have been a sign of culinary excellence, awarded only to the great and good.Georges Blanc, the world’s longest-standing Michelin-starred restaurant, has boasted a three-star rating since 1981, but this month the Michelin guide announced that the restaurant in eastern France was losing a star.
More culinary reputations were enhanced this week, when Asia’s 50 best restaurants for 2025 were revealed. The winner was a Bangkok restaurant which is no stranger to garlands, while second and third place went to two Hong Kong eateries.
You don’t need to go to a heaving metropolis for excellent food, however. A 200-year-old cottage on a remote stretch of Ireland’s Atlantic coast has been given a Michelin star. At the time of awarding, Michelin called it “surely the most rural” of its newest winners.
BillyBew
ゲストMist and microlightning
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To recreate a scenario that may have produced Earth’s first organic molecules, researchers built upon experiments from 1953 when American chemists Stanley Miller and Harold Urey concocted a gas mixture mimicking the atmosphere of ancient Earth. Miller and Urey combined ammonia (NH3), methane (CH4), hydrogen (H2) and water, enclosed their “atmosphere” inside a glass sphere and jolted it with electricity, producing simple amino acids containing carbon and nitrogen. The Miller-Urey experiment, as it is now known, supported the scientific theory of abiogenesis: that life could emerge from nonliving molecules.
For the new study, scientists revisited the 1953 experiments but directed their attention toward electrical activity on a smaller scale, said senior study author Dr. Richard Zare, the Marguerite Blake Wilbur Professor of Natural Science and professor of chemistry at Stanford University in California. Zare and his colleagues looked at electricity exchange between charged water droplets measuring between 1 micron and 20 microns in diameter. (The width of a human hair is 100 microns.)“The big droplets are positively charged. The little droplets are negatively charged,” Zare told CNN. “When droplets that have opposite charges are close together, electrons can jump from the negatively charged droplet to the positively charged droplet.”
The researchers mixed ammonia, carbon dioxide, methane and nitrogen in a glass bulb, then sprayed the gases with water mist, using a high-speed camera to capture faint flashes of microlightning in the vapor. When they examined the bulb’s contents, they found organic molecules with carbon-nitrogen bonds. These included the amino acid glycine and uracil, a nucleotide base in RNA.“We discovered no new chemistry; we have actually reproduced all the chemistry that Miller and Urey did in 1953,” Zare said. Nor did the team discover new physics, he added — the experiments were based on known principles of electrostatics.
“What we have done, for the first time, is we have seen that little droplets, when they’re formed from water, actually emit light and get this spark,” Zare said. “That’s new. And that spark causes all types of chemical transformations.”
KennethTep
ゲストOf course, he said yes to coming back to the series, which eventually required him to live in Italy for a few months for filming.
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During production, White revealed to Gries that Greg is “very sinister.” That became rather irrefutable by the season’s climax, which saw Tanya’s demise orchestrated by her now-husband.Come Season 3, Gries had to rewrite Greg’s backstory again, this time drawing from some unlikely sources for inspiration, like HBO docuseries “The Jinx,” about late convicted killer Robert Durst, and the case involving the man who came to be known as the Tinder Swindler.
Gries said he was struck by Durst’s “kind of seemingly even keel personality,” which served as a model for where Greg was headed, someone “who doesn’t really show a great deal of emotion, doesn’t seem to get too angry, just gets a little bit irritated and is dangerous.”
“There’s a bridled rage underneath. And those kind of people I find – at least with respect to Gary, Greg, Gary – fascinating,” he said.
And yet, while searching for an empathetic way back to portraying his character, Gries kept wondering if there was anything still redeeming about Greg.
An important “wake up moment” came during a decisive conversation he had with White just before filming in Thailand, in which the show’s creator said of Greg, in no uncertain terms: “He’s a psychopath.”“And that was it. It was like, ‘back to the drawing board.’ And it really did help me,” Gries said.
The penultimate episode of the series will air on Sunday, an evening that thanks to “Lotus” and other shows has again become a night of appointment viewing amid a general move away from binge watching. Gries said he appreciates the shift.
“We’re a society that in a weird way doesn’t understand the beauty of waiting. The beauty of the space between the notes,” he shared. “If I binged (‘White Lotus’) I’d feel like I just ate too many chocolates. It just wouldn’t be the same. You need to process this.”
“The White Lotus” airs Sundays at 9 p.m. EDT on HBO, with the episode available to stream on Max. HBO and Max, like CNN, are owned by the same parent company, Warner Bros. Discovery.
AllanAmasp
ゲストA tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
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Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.
Guyana now has the world’s highest expected oil production growth through 2035.
This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.
While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.
Since Exxon’s transformative discovery, Guyana’s government has tightly embraced oil as a route to prosperity. In December 2019, then-President David Granger said in a speech, “petroleum resources will be utilized to provide the good life for all … Every Guyanese will benefit.”It’s a narrative that has continued under current President Mohamed Irfaan Ali, who says new oil wealth will allow Guyana to develop better infrastructure, healthcare and climate adaptation.
TerryPop
ゲストThe voice of ‘White Lotus’ star Walton Goggins is the lullaby we didn’t know we needed
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While his “White Lotus” character Rick has been the source of some stress this season, Walton Goggins is here to soothe us into a state of dreamy sleep to make up for it.The actor has partnered with relaxation and meditation app Calm for one of their famed Sleep Stories, lending his smoky voice to a fable titled “The Yard Sale.”
Goggins announced the Sleep Story on his verified Instagram on Tuesday, writing, “A friend once said to me the first question you ask someone shouldn’t be, ‘How are you?’ but rather, ‘How did you sleep last night?’ I agree.”
The post included an excerpt from the story, in which Goggins is heard languidly instructing listeners to relax their bodies and get into bed. “You could even climb into a hammock,” he added. “I wouldn’t do that because I’ve never gracefully got in or out of one.”
In the caption, the actor also wrote that he “wanted to create a Sleep Story that feels dreamlike, helping people slow their minds down by wandering through a yard sale (which happens to be one of my favorite things to do), uncovering hidden treasures.”
“It’s the Walton Goggins version of counting sheep. I hope you enjoy,” he added.
Other celebrities who have read bedtime stories in the hopes of putting audiences to sleep include Dolly Parton and the late Jimmy Stewart, whose voice was featured in a Calm Christmas Sleep Story in 2023 thanks to generative AI technology.
Goggins currently stars on “The White Lotus,” where his character is often the most stressed out and tortured of the ensemble, at one point setting a slew of snakes free.
Williamfairl
ゲスト“You have a government that is reckless about what is going to happen to Guyana,” said Melinda Janki, an international lawyer in Guyana who is handling several lawsuits against Exxon. It’s pursuing “a supposed course of development that is actually backward and destructive,” she told CNN.
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And while plenty of Guyanese people welcome the new oil industry, some say Guyana’s startling economic statistics do not reflect a real-world prosperity for ordinary people, many of whom are struggling with the higher prices accompanying the oil boom. Inflation rose 6.6% in 2023, with prices of some foods shooting up much more rapidly.“Since the oil extraction began in Guyana, we have noticed that our cost of living has gone sky high,” said Wintress White, of Red Thread, a non-profit that focuses on improving living conditions for Guyanese women. “The money is not trickling down to the masses,” she told CNN.
CNN contacted President Ali, the Ministry of Natural Resources and the Ministry of Finance for comment but received no response.
Guyana, a former Dutch then British colony which gained independence in 1966, is one of only a handful of countries that is a “carbon sink,” meaning it stores more planet-heating pollution than it produces. This is due to its vast rainforest; trees remove carbon dioxide from the atmosphere as they grow.The country has protected its biodiversity where others have destroyed theirs, President Ali said in a BBC interview last year. In 2009, the country signed an agreement with Norway, which promised Guyana more than $250 million to preserve its 18.5 million hectares, or nearly 46 million acres, of forests.
Ali insists the country can balance climate leadership and fossil fuel exploitation. The new oil wealth will allow Guayana to develop, including building climate adaptations such as sea walls, he has said. He has also pointed to the continued failures of wealthy countries, already grown rich on their own fossil fuels, to help poorer countries with climate finance.
But there are concerns Guyana could fall victim to the “resource curse,” in which vast, new wealth ?can actually make life worse for those who live there.
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